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Helping our elderly: Cell-based tools for Alzheimer’s Disease drug screening

Invention Number: 
10_2468
Disease-specific iPSCs provide a powerful research tool to test small molecule candidates for treating diseases.

The Technology

Several disease-specific iPSC clones derived from both the sporadic and familial cases of Alzheimer’s Disease (AD) including derived second generation of neuroprogenitor lines from these iPSC clones with and without GFP label have been fully characterised and are ready for distribution for research and development purposes under licence. A model developed for early detection of AD based on our transcriptomic and proteomic expression analyses will serve as a platform to the pharmaceutical industry for drug discovery and drug toxicity for AD.

There is no cellular model available in the market for an early detection of Alzheimer’s disease. With the emergence of small molecule and protein therapeutic discovery, these disease-specific iPSCs can be used for small molecule candidates for treating diseases. In addition to discovering new therapeutics, iPSCs cellular disease models can be used to systematically perturb cells in vitro in order to elucidate mechanisms of disease.

AD-specific iPSC clone, NPC differentiated to neuronal cells

Business Opportunity

AD-specific iPSC clones derived from both sporadic and familial patient’s skin express the downstream disease-specific metabolic pathways and provide an excellent tool for disease modelling drug discovery including drug toxicity for AD for which there is no effective cure available.

The Market

The screening of drug candidates for toxicity is a major cause of attrition in drug development that leads to high costs and reduced number of effective clinical candidates. There is a need for early stage screening of toxic candidates for cost effective development of novel therapeutic agents.

The Team

Professor Perminder Sachdev
Scientist of the Year 2010
School of Biomedical Sciences, UNSW

Associate Professor Kuldip Sidhu
Director of the Stem cell Laboratory, UNSW
2007 Eureka Prize Finalist

Investment Opportunity

UNSW Innovations is looking to partner with companies interested in commercialising these unique cell lines.